The CNS glycoprotein Shadoo has PrPC-like protective properties and displays reduced levels in prion infections

  title={The CNS glycoprotein Shadoo has PrPC-like protective properties and displays reduced levels in prion infections},
  author={Joel C. Watts and Bettina Drisaldi and Vivian Ng and Jing Yang and Bob Strome and Patrick Horne and M Ourey Sy and Larry Yoong and Rebecca W. Young and Peter Mastrangelo and Catherine Racicot Bergeron and Paul E. Fraser and George A. Carlson and Howard T. J. Mount and Gerold Schmitt-Ulms and David Westaway},
  journal={The EMBO Journal},
  pages={4038 - 4050}
The cellular prion protein, PrP(C), is neuroprotective in a number of settings and in particular prevents cerebellar degeneration mediated by CNS-expressed Doppel or internally deleted PrP ('DeltaPrP'). This paradigm has facilitated mapping of activity determinants in PrP(C) and implicated a cryptic PrP(C)-like protein, 'pi'. Shadoo (Sho) is a hypothetical GPI-anchored protein encoded by the Sprn gene, exhibiting homology and domain organization similar to the N-terminus of PrP. Here we… CONTINUE READING
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