The CNS glycoprotein Shadoo has PrPC-like protective properties and displays reduced levels in prion infections

  title={The CNS glycoprotein Shadoo has PrPC-like protective properties and displays reduced levels in prion infections},
  author={Joel C. Watts and B. Drisaldi and Vivian M W Ng and Jing Yang and Bob Strome and P. Horne and M. Sy and Larry Yoong and R. Young and P. Mastrangelo and C. Bergeron and P. Fraser and G. Carlson and H. Mount and G. Schmitt-Ulms and D. Westaway},
  journal={The EMBO Journal},
  pages={4038 - 4050}
  • Joel C. Watts, B. Drisaldi, +13 authors D. Westaway
  • Published 2007
  • Biology, Medicine
  • The EMBO Journal
  • The cellular prion protein, PrPC, is neuroprotective in a number of settings and in particular prevents cerebellar degeneration mediated by CNS‐expressed Doppel or internally deleted PrP (‘ΔPrP’). This paradigm has facilitated mapping of activity determinants in PrPC and implicated a cryptic PrPC‐like protein, ‘π’. Shadoo (Sho) is a hypothetical GPI‐anchored protein encoded by the Sprn gene, exhibiting homology and domain organization similar to the N‐terminus of PrP. Here we demonstrate Sprn… CONTINUE READING
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