The CNK2 Scaffold Interacts with Vilse and Modulates Rac Cycling during Spine Morphogenesis in Hippocampal Neurons

@article{Lim2014TheCS,
  title={The CNK2 Scaffold Interacts with Vilse and Modulates Rac Cycling during Spine Morphogenesis in Hippocampal Neurons},
  author={Junghwa Lim and Daniel A. Ritt and Ming Zhou and Deborah K. Morrison},
  journal={Current Biology},
  year={2014},
  volume={24},
  pages={786-792}
}
Protein scaffolds play an important role in signal transduction, functioning to facilitate protein interactions and localize key pathway components to specific signaling sites. Connector enhancer of KSR-2 (CNK2) is a neuronally expressed scaffold recently implicated in nonsyndromic, X-linked intellectual disability (NS-XLID) [1-3]. NS-XLID patients have deficits in cognitive function and their neurons often exhibit dendritic spine abnormalities [4], suggesting a role for CNK2 in synaptic… CONTINUE READING