The CLOCK gene and mood disorders: a case-control study and meta-analysis.

  title={The CLOCK gene and mood disorders: a case-control study and meta-analysis.},
  author={Taro Kishi and Reiji Yoshimura and Yasuhisa Fukuo and Tsuyoshi Kitajima and Tomo Okochi and Shinji Matsunaga and Toshiya Inada and Hiroshi Kunugi and Tadafumi Kato and Takeo Yoshikawa and Hiroshi Ujike and Wakako Umene-Nakano and Jun - Ichi Sagara Shugo Nakamura and Norio Ozaki and Alessandro Serretti and Christoph U Correll and Nakao Iwata},
  journal={Chronobiology international},
  volume={28 9},
The clock gene (CLOCK) is considered to be a good candidate gene for the pathophysiology of mood disorders, including bipolar disorder (BP) and major depressive disorder (MDD). rs1801260 (T3111C) has been detected at position 3111 in the CLOCK mRNA 3' untranslated region, and was reported to be associated with a substantial delay in preferred timing for activity and sleep in a human study. As for function, rs1801260 has been speculated to affect mRNA. Therefore, the authors investigated the… CONTINUE READING
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