The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins.

  title={The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins.},
  author={Anthony J. Baines and Paola A Bignone and Mikayala D A King and Alison M. Maggs and Pauline M Bennett and Jennifer Pinder and Gareth W. Phillips},
  journal={Molecular biology and evolution},
  volume={26 9},
We describe a structural domain common to proteins related to human calmodulin-regulated spectrin-associated protein1 (CAMSAP1). Analysis of the sequence of CAMSAP1 identified a domain near the C-terminus common to CAMSAP1 and two other mammalian proteins KIAA1078 and KIAA1543, which we term a CKK domain. This domain was also present in invertebrate CAMSAP1 homologues and was found in all available eumetazoan genomes (including cnidaria), but not in the placozoan Trichoplax adherens, nor in any… CONTINUE READING


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