The CK2 Kinase Stabilizes CLOCK and Represses Its Activity in the Drosophila Circadian Oscillator

@inproceedings{Szab2013TheCK,
  title={The CK2 Kinase Stabilizes CLOCK and Represses Its Activity in the Drosophila Circadian Oscillator},
  author={{\'A}ron Szab{\'o} and Christian Papin and Daniela Zorn and Prishila Ponien and Frank Weber and Thomas Raabe and François Rouyer},
  booktitle={PLoS biology},
  year={2013}
}
Phosphorylation is a pivotal regulatory mechanism for protein stability and activity in circadian clocks regardless of their evolutionary origin. It determines the speed and strength of molecular oscillations by acting on transcriptional activators and their repressors, which form negative feedback loops. In Drosophila, the CK2 kinase phosphorylates and destabilizes the PERIOD (PER) and TIMELESS (TIM) proteins, which inhibit CLOCK (CLK) transcriptional activity. Here we show that CK2 also… CONTINUE READING
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