The CHiPS Domain--ancient traces for the Hermansky-Pudlak syndrome.

@article{HoffmanSommer2005TheCD,
  title={The CHiPS Domain--ancient traces for the Hermansky-Pudlak syndrome.},
  author={Marta Hoffman-Sommer and Marcin Grynberg and Roza Kucharczyk and Joanna Rytka},
  journal={Traffic},
  year={2005},
  volume={6 7},
  pages={
          534-8
        }
}
Hermansky-Pudlak syndrome (HPS) is a rare disorder caused by malfunctions of lysosomes and specialized lysosome-related organelles, resulting primarily in oculocutaneous albinism and bleeding diathesis. The majority of the HPS genes have been described as novel, but herein we report the identification of a conserved protein family which includes human HPS4, as well as distant homologs for other HPS genes. Our results suggest that the cellular machinery involved in the HPS syndrome is ancient. 

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