The CHFR mitotic checkpoint protein delays cell cycle progression by excluding Cyclin B1 from the nucleus

@article{Summers2005TheCM,
  title={The CHFR mitotic checkpoint protein delays cell cycle progression by excluding Cyclin B1 from the nucleus},
  author={Matthew K. Summers and John Bothos and Thanos D Halazonetis},
  journal={Oncogene},
  year={2005},
  volume={24},
  pages={2589-2598}
}
CHFR, a novel checkpoint gene inactivated in human cancer, delays chromosome condensation in cells treated with microtubule poisons. To understand the molecular mechanism for this delay, we characterized cells with inactivated CHFR and stably transfected derivatives expressing the wild-type gene. After exposure to microtubule poisons, the CHFR-expressing cells arrested transiently in early prophase with a characteristic ruffled morphology of the nuclear envelope and no signs of chromosome… CONTINUE READING