The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population.

@article{Kleibl2009TheCG,
  title={The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population.},
  author={Zdenek Kleibl and Ondřej Havr{\'a}nek and Ivona Hlavat{\'a} and Jan Novotn{\'y} and Jan {\vS}ev{\vc}{\'i}k and Petr Pohlreich and Pavel Soucek},
  journal={European journal of cancer},
  year={2009},
  volume={45 4},
  pages={618-24}
}
Checkpoint kinase 2 (CHEK2) gene codes for an important mediator of DNA damage response pathway. Its mutations increase risk of several types of cancer. We analysed selected CHEK2 mutations in 631 Czech colorectal cancer (CRC) patients. The increased risk of CRC was associated with mutations in CHEK2 gene region involving fork head-associated domain [39/631 (6.2%) cases versus 19/683 (2.8%) controls; odds ratio (OR)=2.3; 95% confidence interval (CI)=1.3-4.0; p=0.003], and with the most frequent… CONTINUE READING