The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing.

@article{Ladd2001TheCF,
  title={The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing.},
  author={Andrea N. Ladd and Nicolas Charlet and Thomas A. Cooper},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 4},
  pages={
          1285-96
        }
}
Alternative splicing of cardiac troponin T (cTNT) exon 5 undergoes a developmentally regulated switch such that exon inclusion predominates in embryonic, but not adult, striated muscle. We previously described four muscle-specific splicing enhancers (MSEs) within introns flanking exon 5 in chicken cTNT that are both necessary and sufficient for exon inclusion in embryonic muscle. We also demonstrated that CUG-binding protein (CUG-BP) binds a conserved CUG motif within a human cTNT MSE and… CONTINUE READING

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