The CDR1 of the human lambdaVI light chains adopts a new canonical structure.

@article{Yauner2006TheCO,
  title={The CDR1 of the human lambdaVI light chains adopts a new canonical structure.},
  author={L del Pozo Yauner and Ernesto Ortiz and Baltazar Becerril},
  journal={Proteins},
  year={2006},
  volume={62 1},
  pages={
          122-9
        }
}
We performed a comparative analysis of the conformation of the CDR1 of the human lambdaVI variable domains JTO and WIL and the equivalent loop of the lambdaI light chains RHE and KOL, which are representative of the type I canonical structure for lambda light chains. On the basis of the differences found in the main chain conformation, as well as the identity of the residues at key positions, we showed that the L1 of some lambdaVI light chains adopts a conformation that represents a new type of… CONTINUE READING