The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity.

@article{Napolitano1999TheCC,
  title={The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity.},
  author={Gennaro Napolitano and Paolo Licciardo and Paolo Gallo and Barbara Majello and Alessia Giordano and Luigi Lania},
  journal={AIDS},
  year={1999},
  volume={13 12},
  pages={1453-9}
}
OBJECTIVES To examine the functional interaction between HIV-1 Tat protein and the cyclin T1 and T2 proteins which, in association with cyclin dependent kinase (CDK)9, are the regulatory subunits of the TAK/P-TEFb cellular complex strictly required for Tat transactivation. DESIGN HIV-1 long terminal repeat (LTR) reporter plasmid was co-transfected into… CONTINUE READING