The CDK9/Cyclin T1 subunits of P-TEFb in mouse oocytes and preimplantation embryos: A possible role in embryonic genome activation

@inproceedings{Oqani2011TheCT,
  title={The CDK9/Cyclin T1 subunits of P-TEFb in mouse oocytes and preimplantation embryos: A possible role in embryonic genome activation},
  author={Reza Kheirkhahi Oqani and Hong Rye Kim and Yun Fei Diao and Chang Sik Park and Dong Il Jin},
  booktitle={BMC Developmental Biology},
  year={2011}
}
Two stages of genome activation have been identified in the mouse embryo. Specifically, minor transcriptional activation is evident at the one-cell stage and a second major episode of activation occurs at the two-cell stage. Nuclear translocation of RNA polymerase II and phosphorylation of the C-terminal domain (CTD) of the largest enzyme subunit are major determinants of embryonic genome activation. P-TEFb, the Pol II CTD kinase, regulates transcriptional elongation via phosphorylation of the… CONTINUE READING
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