The CDK inhibitor p21Cip1/WAF1 is induced by FcγR activation and restricts HIV-1 replication in human macrophages

Abstract

Background Macrophages are major targets of human immunodeficiency virus type 1 (HIV-1) infection. We have previously shown that the engagement of the activating Fc receptors of the IgG (FcγR) by immune complexes (IC) suppresses the replication of HIV-1 and related lentiviruses in monocyte-derived macrophages, inhibiting both the accumulation of reverse transcripts and the proviral integration [1].

DOI: 10.1186/1742-4690-6-S2-P11

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@article{Bergamaschi2009TheCI, title={The CDK inhibitor p21Cip1/WAF1 is induced by FcγR activation and restricts HIV-1 replication in human macrophages}, author={Anna Bergamaschi and Annie David and Erwann Le Rouzic and S{\'e}bastien Nisole and Françoise Barr{\'e}-Sinoussi and Gianfranco Pancino}, journal={Retrovirology}, year={2009}, volume={6}, pages={P11 - P11} }