The CD95(APO-1/Fas) DISC and beyond

  title={The CD95(APO-1/Fas) DISC and beyond},
  author={Marcus E Peter and Peter Heinrich Krammer},
  journal={Cell Death and Differentiation},
AbstractCD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC). The DISC consists of an adaptor protein and initiator… CONTINUE READING
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