The CD94/NKG2-A inhibitory receptor complex is involved in natural killer cell-mediated recognition of cells expressing HLA-G1.

@article{PrezVillar1997TheCI,
  title={The CD94/NKG2-A inhibitory receptor complex is involved in natural killer cell-mediated recognition of cells expressing HLA-G1.},
  author={Juan Jos{\'e} P{\'e}rez-Villar and Ignacio Melero and Francisco F Navarro and Marta Carretero and Teresa Bell{\'o}n and Manuel Llano and Marco Colonna and Daniel E. Geraghty and Miguel L{\'o}pez-Botet},
  journal={Journal of immunology},
  year={1997},
  volume={158 12},
  pages={5736-43}
}
Human NK cells bear surface receptors that inhibit their cytolytic activity upon specific recognition of MHC class Ia Ags; little is known about the capacity of class Ib molecules to regulate NK cell function. We have studied the roles of different NK inhibitory receptors in recognition of the class Ib HLA-G. To this end, we analyzed the ability of an HLA-defective tumor cell line (721.221) transfected with the membrane form of HLA-G1, which contains the three external domains, to inhibit the… CONTINUE READING

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