The CD8+ memory T-cell state of readiness is actively maintained and reversible.

@article{Allam2009TheCM,
  title={The CD8+ memory T-cell state of readiness is actively maintained and reversible.},
  author={Atef Allam and Dietrich B. Conze and Maria Letizia Giardino Torchia and Ivana Munitic and H. Yagita and Ryan T Sowell and Amanda L. Marzo and Jonathan D Ashwell},
  journal={Blood},
  year={2009},
  volume={114 10},
  pages={2121-30}
}
The ability of the adaptive immune system to respond rapidly and robustly upon repeated antigen exposure is known as immunologic memory, and it is thought that acquisition of memory T-cell function is an irreversible differentiation event. In this study, we report that many phenotypic and functional characteristics of antigen-specific CD8 memory T cells are lost when they are deprived of contact with dendritic cells. Under these circumstances, memory T cells reverted from G(1) to the G(0) cell… CONTINUE READING