The CD7− subset of CD4+ memory T cells is prone to accelerated apoptosis that is prevented by interleukin-15 (IL-15)

Abstract

The CD7− subset of CD4+ T cells reflects a stable differentiation state of post-thymic helper T cells with CD45R0+CD45RA− ‘memory’ phenotype. Here we report that CD4+CD7− T cells are prone to increased spontaneous apoptosis in vitro compared to CD4+CD7+ T cells. Spontaneous apoptosis is prevented by IL-15, but not by IL-2. Moreover, IL-15 increases Bcl-2… (More)
DOI: 10.1038/sj.cdd.4400825

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@article{Rappl2001TheCS, title={The CD7− subset of CD4+ memory T cells is prone to accelerated apoptosis that is prevented by interleukin-15 (IL-15)}, author={Gunter Rappl and Hinrich Abken and Dieter Hasselmann and Wolfgang Tilgen and Selma Ugurel and Uwe Reinhold}, journal={Cell Death and Differentiation}, year={2001}, volume={8}, pages={395-402} }