The CD58 (LFA-3) binding site is a localized and highly charged surface area on the AGFCC'C" face of the human CD2 adhesion domain.

@article{Arulanandam1993TheC,
  title={The CD58 (LFA-3) binding site is a localized and highly charged surface area on the AGFCC'C" face of the human CD2 adhesion domain.},
  author={Antonio R N Arulanandam and Jane M. Withka and Daniel F. Wyss and Gerhard Wagner and Alexander Kister and Peter V. Pallai and M A Recny and Ellis L. Reinherz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 24},
  pages={11613-7}
}
Using site-directed mutagenesis in conjunction with NMR structural data on the adhesion domain of human CD2, we have defined the binding region for CD58. Previous structural studies of rat and human CD2 indicate that this adhesion domain is immunoglobulin-like. Here we report that the CD58 binding site is a well-circumscribed, charged surface area covering approximately 770 A2 on the AGFCC'C" face of the CD2 beta barrel. This site contains beta-strand residues in the carboxyl-terminal half of… CONTINUE READING