The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling.

@article{Donners2008TheCA,
  title={The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling.},
  author={M Donners and L. J. Beckers and Dirk Lievens and Imke C. A. Munnix and Johan W. M. Heemskerk and Ben J. A. Janssen and Erwin Wijnands and Jack P. M. Cleutjens and Alma Zernecke and Christian Weber and Cory L. Ahonen and Ulrike Benbow and Andrew C Newby and Randolph J. Noelle and Mat J. A. P. Daemen and Esther Lutgens},
  journal={Blood},
  year={2008},
  volume={111 9},
  pages={4596-604}
}
We investigated the role of CD40 and CD40L in neointima formation and identified the downstream CD40-signaling intermediates (tumor necrosis factor [TNF]-receptor associated factors [TRAF]) involved. Neointima formation was induced in wild-type, CD40(-/-), CD40L(-/-), and in CD40(-/-) mice that contained a CD40 transgene with or without mutations at the CD40-TRAF2,3&5, TRAF6, or TRAF2,3,5&6 binding sites. Compared with wild-type mice, CD40(-/-) mice showed a significant decrease in neointima… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Similar Papers

Loading similar papers…