The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cells in inflammatory bowel disease.

@article{Borcherding2010TheCP,
  title={The CD40-CD40L pathway contributes to the proinflammatory function of intestinal epithelial cells in inflammatory bowel disease.},
  author={Frauke Borcherding and Martin Nitschke and Gheorghe Hundorfean and Jan Rupp and Dorthe von Smolinski and Katja Bieber and Cees van Kooten and Hendrik Lehnert and Klaus Fellermann and Juergen Buening},
  journal={The American journal of pathology},
  year={2010},
  volume={176 4},
  pages={1816-27}
}
In inflammatory bowel diseases (IBD), intestinal epithelial cells (IECs) are involved in the outbalanced immune responses toward luminal antigens. However, the signals responsible for this proinflammatory capacity of IECs in IBD remain unclear. The CD40/CD40L interaction activates various pathways in immune and nonimmune cells related to inflammation and was shown to be critical for the development of IBD. Here we demonstrate CD40 expression within IECs during active IBD. Endoscopically… CONTINUE READING
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