The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis.

Abstract

BACKGROUND Blockade of CD40-CD40 ligand (CD154) interactions protects against renal injury in adriamycin nephropathy (AN) in immunocompetent mice. To investigate whether this protection relied on adaptive or cognate immunity, we tested the effect of CD40-CD154 blockade in severe combined immunodeficient (SCID) mice. METHODS SCID mice were divided into… (More)
DOI: 10.1093/ndt/gfp569

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