The CD40/CD40L system: a new therapeutic target for disease.

  title={The CD40/CD40L system: a new therapeutic target for disease.},
  author={Bikui Zhang and Tian Wu and Min Chen and Yulu Zhou and Dongyang Yi and Ren Yong Guo},
  journal={Immunology letters},
  volume={153 1-2},
The role of CD40/CD40 ligand (CD40L) interactions in atherothrombosis, in the response of the immune system to pathogens and in thrombosis is now widely accepted. A role for CD40-CD40L interactions has been identified in atherosclerosis (AS), and such interactions are known to destabilize atherosclerotic plaques by inducing the expression of cytokines, chemokines, growth factors, matrix metalloproteinases and pro-coagulant factors. CD40/CD40L interactions have also been implicated in immune… CONTINUE READING


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