The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
@article{Dalgleish1984TheC, title={The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus}, author={Angus George Dalgleish and Peter C. L. Beverley and Paul R. Clapham and Dorothy H. Crawford and Mel Greaves and Robin A. Weiss}, journal={Nature}, year={1984}, volume={312}, pages={763-767} }
Acquired immune deficiency syndrome (AIDS) is characterized by opportunistic infections and by ‘opportunistic neoplasms’ (for example, Kaposi's sarcoma)1. Persistent generalized lymphadenopathy (PGL) is epidemiologically associated with AIDS, especially in male homosexuals. A subset of T lymphocytes positive for the CD4 antigen2 (also termed T4 antigen), is depleted in AIDS and PGL patients. A retrovirus found in T-cell cultures from these patients3–5 is strongly implicated in the aetiology of…
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T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV
- BiologyNature
- 1984
Preincubation of T4+ lymphocytes with three individual monoclonal antibodies directed at the T4 glycoprotein blocked cell infection by LAV, strongly support the view that a surface molecule directly involved in cellular functions acts as, or is related to, the receptor for a human retrovirus.
AIDS as a consequence of la antigen recognition: a closer look.
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The Role of CD4 Antigen in HIV Infection
- Biology, Medicine
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Cell surface glycoproteins that are members of the immunoglobulin superfamily have been shown to act as viral receptors, namely ICAM-1 for the major group of rhinoviruses, and a hitherto unknown antigen as the polio receptor.
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- Medicine, BiologyThe American journal of pathology
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It is indicated that the network of follicular dendritic cells is an important reservoir of AV virus antigen at this site, and the persistence of this retrovirus inside the GCs helps explain how the follicular hyperplasia affecting FD cells and B blasts in PGL may in progressive cases be accompanied by destruction ofFD cells and gradual development of T4+ lymphopenia.
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The basis for the specific cytotoxicity of the virus is investigated, and it is reported that high-level expression of the HTLV-III envelope gene induces syncytia and concomitant cell death in T4+ cell lines but not in a B-lymphocyte line.
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The properties of the in vitro infection have led several investigators to hypothesize that long-lived tissue macrophages might serve as a reservoir for HIV infection in vivo, as recent studies have shown that patients with HIV infection develop progressively increasing titers of virus in plasma with time.
Immunopathogenesis of AIDS
- Medicine, Biology
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It is clear that HIV-i induces dysfunction of almost all of the elements of the immune system and that the pathogenetic mechanisms of the disease progression are multifactorial.
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- Biology, Medicine
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Immunological abnormalities have been observed in asymptomatic HIV-infected people with normal CD4+ T cell numbers, indicating that HIV affects the immune system before T cell depletion ensues.
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