The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

@article{Dalgleish1984TheC,
  title={The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus},
  author={Angus George Dalgleish and Peter C. L. Beverley and Paul R. Clapham and Dorothy H. Crawford and Mel Greaves and Robin A. Weiss},
  journal={Nature},
  year={1984},
  volume={312},
  pages={763-767}
}
Acquired immune deficiency syndrome (AIDS) is characterized by opportunistic infections and by ‘opportunistic neoplasms’ (for example, Kaposi's sarcoma)1. Persistent generalized lymphadenopathy (PGL) is epidemiologically associated with AIDS, especially in male homosexuals. A subset of T lymphocytes positive for the CD4 antigen2 (also termed T4 antigen), is depleted in AIDS and PGL patients. A retrovirus found in T-cell cultures from these patients3–5 is strongly implicated in the aetiology of… 
T-lymphocyte T4 molecule behaves as the receptor for human retrovirus  LAV
TLDR
Preincubation of T4+ lymphocytes with three individual monoclonal antibodies directed at the T4 glycoprotein blocked cell infection by LAV, strongly support the view that a surface molecule directly involved in cellular functions acts as, or is related to, the receptor for a human retrovirus.
AIDS as a consequence of la antigen recognition: a closer look.
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It isested that recognition of allogeneic la or class II major histocompatibility complex (MHC) antigenic determinants was responsible for initiation of the immune defects in AIDS and GVHID, and suggested that increased levels of self-LA antigens or modified self-la resulting from the AIDS infectious agent could contribute to the immune-deficient state.
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TLDR
Cell surface glycoproteins that are members of the immunoglobulin superfamily have been shown to act as viral receptors, namely ICAM-1 for the major group of rhinoviruses, and a hitherto unknown antigen as the polio receptor.
Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity
TLDR
The basis for the specific cytotoxicity of the virus is investigated, and it is reported that high-level expression of the HTLV-III envelope gene induces syncytia and concomitant cell death in T4+ cell lines but not in a B-lymphocyte line.
Clinical and biological characteristics of malignant lymphomas in HIV-infected patients.
TLDR
Severe immunodeficiency together with chronic antigenicimitogenic stimulation has been associated with lymphoid malignancies, and HIV infection may be considered as a prelymphomatous state.
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TLDR
HIV infection is primarily productive and lytic, at least in cell cultures, and in viva, viral destruction of T-helper lymphocytes is thought to be a major cause of death.
Mediators of fusion between HIV-infected macrophages and lymphoid cells.
TLDR
The properties of the in vitro infection have led several investigators to hypothesize that long-lived tissue macrophages might serve as a reservoir for HIV infection in vivo, as recent studies have shown that patients with HIV infection develop progressively increasing titers of virus in plasma with time.
Immunopathogenesis of AIDS
TLDR
It is clear that HIV-i induces dysfunction of almost all of the elements of the immune system and that the pathogenetic mechanisms of the disease progression are multifactorial.
Lymphocyte functional analysis in HIV infection: mechanisms and clinical relevance
TLDR
Immunological abnormalities have been observed in asymptomatic HIV-infected people with normal CD4+ T cell numbers, indicating that HIV affects the immune system before T cell depletion ensues.
Follicular Dendritic Cells, Human Immunodeficiency Virus Type-1, And Alpha-1-Antitrypsin
TLDR
It is suggested that alpha-1-antitrypsin (AAT) not only suppresses HIV replication, but also blocks HIV replication in CD4+ T cells, thereby affecting the trapping and maintenance of HIV.
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TLDR
Preincubation of T4+ lymphocytes with three individual monoclonal antibodies directed at the T4 glycoprotein blocked cell infection by LAV, strongly support the view that a surface molecule directly involved in cellular functions acts as, or is related to, the receptor for a human retrovirus.
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  • P. Clapham, K. Nagy, R. Weiss
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1984
TLDR
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