The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

@article{Dalgleish1984TheC,
  title={The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus},
  author={Angus George Dalgleish and Peter C. L. Beverley and Paul R. Clapham and Dorothy H. Crawford and Mel Greaves and Robin A. Weiss},
  journal={Nature},
  year={1984},
  volume={312},
  pages={763-767}
}
Acquired immune deficiency syndrome (AIDS) is characterized by opportunistic infections and by ‘opportunistic neoplasms’ (for example, Kaposi's sarcoma)1. Persistent generalized lymphadenopathy (PGL) is epidemiologically associated with AIDS, especially in male homosexuals. A subset of T lymphocytes positive for the CD4 antigen2 (also termed T4 antigen), is depleted in AIDS and PGL patients. A retrovirus found in T-cell cultures from these patients3–5 is strongly implicated in the aetiology of… 
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    Proceedings of the National Academy of Sciences of the United States of America
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