The CD4‐related molecule, LAG‐3 (CD223), regulates the expansion of activated T cells

@article{Workman2003TheCM,
  title={The CD4‐related molecule, LAG‐3 (CD223), regulates the expansion of activated T cells},
  author={Creg J. Workman and Dario A A Vignali},
  journal={European Journal of Immunology},
  year={2003},
  volume={33}
}
The lymphocyte activation gene‐3 (LAG‐3, CD223) is a CD4‐related, activation‐induced cell surface molecule that binds to MHC class II with high affinity. The function of murine LAG‐3 on T cells is unclear. Here, we show that Vβ7/8+LAG‐3–/– T cells expand poorly following staphylococcal enterotoxin B (SEB) stimulation in vitro. LAG‐3–/– T cells proliferate at a normal rate, but exhibit increased cell death. Similar observations were made with LAG‐3–/–CD4+OT‐II TCR transgenic T cells following… Expand

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