The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation.

@article{Riley2005TheCF,
  title={The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation.},
  author={James L Riley and Carl H June},
  journal={Blood},
  year={2005},
  volume={105 1},
  pages={
          13-21
        }
}
The CD28 family of receptors (CD28, cytotoxic T-lymphocyte-associated antigen 4 [CTLA-4], inducible costimulator [ICOS], program death-1 [PD-1], and B- and T-lymphocyte attenuator [BTLA]) plays a critical role in controlling the adaptive arm of the immune response. While considerable information is available regarding CD28 and CTLA-4, the function of the more recently discovered members of the CD28 family is less well understood. This review will highlight recent findings regarding the CD28… CONTINUE READING

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 113 CITATIONS, ESTIMATED 62% COVERAGE

Modulation of T regulatory activity for cancer therapy

VIEW 14 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Viral modulation of T-cell receptor signaling.

  • Journal of virology
  • 2008
VIEW 9 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2005
2018

CITATION STATISTICS

  • 6 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 131 REFERENCES

Conversion of CTLA-4 form inhibitor to activator of T cells with a bispecific tandem single-chain variable region fragments ligand

J Madrenas, LA Chau, WA Teft
  • J Immunol
  • 2004

Inducible costimulator-dependent IL-10 production by regulatory T cells specific for self-antigen.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004