The CD20 homolog Ms4a8a integrates pro- and anti-inflammatory signals in novel M2-like macrophages and is expressed in parasite infection.

@article{Schmieder2012TheCH,
  title={The CD20 homolog Ms4a8a integrates pro- and anti-inflammatory signals in novel M2-like macrophages and is expressed in parasite infection.},
  author={Astrid Schmieder and Kai Schledzewski and Julia Michel and Kathrin Sch{\"o}nhaar and Yannick Morias and Tom Bosschaerts and Jan Van den Bossche and Pierre Dorny and Andrea Sauer and Carsten Sticht and Cyrill G{\'e}raud and Zoe Waibler and Alain Beschin and Sergij Goerdt},
  journal={European journal of immunology},
  year={2012},
  volume={42 11},
  pages={2971-82}
}
Recently, we identified the CD20 homolog Ms4a8a as a novel molecule expressed by tumor-associated macrophages that directly enhances tumor growth. Here, we analyzed Ms4a8a(+) macrophages in M2-associated infectious pathologies. In late-stage Trypanosoma congolense and Taenia crassiceps infections, Ms4a8a expression was detected in hepatic and peritoneal macrophages respectively. Innate immunity in these infections is modulated by Toll-like receptor (TLR) signaling and TLR2/4/7 agonists strongly… CONTINUE READING
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