The CD20 homolog Ms4a8a integrates pro‐ and anti‐inflammatory signals in novel M2‐like macrophages and is expressed in parasite infection

@article{Schmieder2012TheCH,
  title={The CD20 homolog Ms4a8a integrates pro‐ and anti‐inflammatory signals in novel M2‐like macrophages and is expressed in parasite infection},
  author={A. Schmieder and K. Schledzewski and J. Michel and K. Sch{\"o}nhaar and Yannick Morias and T. Bosschaerts and J. Van den Bossche and P. Dorny and A. Sauer and C. Sticht and C. G{\'e}raud and Z. Waibler and A. Beschin and S. Goerdt},
  journal={European Journal of Immunology},
  year={2012},
  volume={42}
}
  • A. Schmieder, K. Schledzewski, +11 authors S. Goerdt
  • Published 2012
  • Biology, Medicine
  • European Journal of Immunology
  • Recently, we identified the CD20 homolog Ms4a8a as a novel molecule expressed by tumor‐associated macrophages that directly enhances tumor growth. Here, we analyzed Ms4a8a+ macrophages in M2‐associated infectious pathologies. In late‐stage Trypanosoma congolense and Taenia crassiceps infections, Ms4a8a expression was detected in hepatic and peritoneal macrophages respectively. Innate immunity in these infections is modulated by Toll‐like receptor (TLR) signaling and TLR2/4/7 agonists strongly… CONTINUE READING
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