The CD2-LFA-3 and LFA-1-ICAM pathways: relevance to T-cell recognition.

  title={The CD2-LFA-3 and LFA-1-ICAM pathways: relevance to T-cell recognition.},
  author={Malegapuru William Makgoba and Martin E. Sanders and Stephen Shaw},
  journal={Immunology today},
  volume={10 12},
No process is more central to T-lymphocyte function than cell-cell adhesion, yet it is only recently that interest in lymphocyte adhesion has burgeoned. Neglect of adhesion is particularly surprising since immunologists are surrounded by a veritable sea of adhesive interactions of lymphocytic cells: transformed lymphocytes grow in aggregates, stimulated lymphocytes aggregate and T cells conjugate with their targets. In retrospect, it is obvious that all lymphocyte adhesion (both antigen… CONTINUE READING

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