The CD169 sialoadhesin molecule mediates cytotoxic T-cell responses to tumour apoptotic vesicles.

@article{Black2016TheCS,
  title={The CD169 sialoadhesin molecule mediates cytotoxic T-cell responses to tumour apoptotic vesicles.},
  author={Lane Vc Black and Sarah C Saunderson and Frazer P Coutinho and Morad-R{\'e}my Muhsin-Sharafaldine and Tanvi T. Damani and Amy C. Dunn and Alexander Donald McLellan},
  journal={Immunology and cell biology},
  year={2016},
  volume={94 5},
  pages={
          430-8
        }
}
Apoptosis leads to the fragmentation and packaging of cellular contents into discrete vesicles, a process known as 'blebbing'. Extracellular vesicles express membrane-bound sialic acids, which enable their capture by CD169 (sialoadhesin; Siglec-1) expressing macrophages in the lymph node and spleen. Furthermore, CD169 mediates vesicle trafficking and suppresses the immune response to exosomes-a type of extracellular vesicle released from living cells. In this study, we found that CD169… CONTINUE READING
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