The CD155/poliovirus receptor enhances the proliferation of ras‐mutated cells

@article{Kono2008TheCR,
  title={The CD155/poliovirus receptor enhances the proliferation of ras‐mutated cells},
  author={Tokuyuki Kono and Yasuo Imai and Shin-ichi Yasuda and Kyoko Ohmori and Hirokazu Fukui and Kazuhito Ichikawa and Shigeki Tomita and Johji Imura and Yoshikazu Kuroda and Yoshihiko Ueda and Takahiro Fujimori},
  journal={International Journal of Cancer},
  year={2008},
  volume={122}
}
Stimulation of the CD155/poliovirus receptor, which localizes in the cell–matrix and at cell–cell junctions, inhibits cell adhesion and enhances cell migration. Necl‐5, a mouse homolog of CD155, is implicated in the formation of adherence junctions. Recently, Necl‐5 has also been found to enhance cell proliferation via the stimulation of serum and platelet‐derived growth factor through the Ras‐Raf‐MEK‐ERK signaling pathway. In our present study, we find that CD155 significantly enhances the… 
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References

SHOWING 1-10 OF 35 REFERENCES
Ligand stimulation of CD155alpha inhibits cell adhesion and enhances cell migration in fibroblasts.
Enhancement of Serum- and Platelet-derived Growth Factor-induced Cell Proliferation by Necl-5/Tage4/Poliovirus Receptor/CD155 through the Ras-Raf-MEK-ERK Signaling*
TLDR
Results indicate that Necl-5 plays roles not only in cell motility but also in cell proliferation, as well as being involved at least partly in the enhanced proliferation of transformed cells including NIH3T3 cells transformed by an oncogenic Ras or v-Src.
Nectin-like Molecule-5/Tage4 Enhances Cell Migration in an Integrin-dependent, Nectin-3-independent Manner*
TLDR
Results indicate that Necl-5 regulates serum- and platelet-derived growth factor-induced cell migration in an integrin-dependent, nectin-3-independent manner, when cells do not contact other cells.
CD155/PVR enhances glioma cell dispersal by regulating adhesion signaling and focal adhesion dynamics.
TLDR
It is shown that expression of CD155/PVR in rat glioma cells that normally lack this protein enhances their dispersal both in vitro and on primary brain tissue, and suggests a pathway through which gliomas and other cancer cells may acquire a dispersive phenotype.
p27Kip1 and Cyclin D1 Are Necessary for Focal Adhesion Kinase Regulation of Cell Cycle Progression in Glioblastoma Cells Propagated in Vitro and in Vivo in the Scid Mouse Brain*
TLDR
The results indicate that FAK promotes proliferation of glioblastoma cells by enhancing exit from G1 through a mechanism that involves cyclin D1 and p27Kip1.
Recruitment of Nectin-3 to Cell-Cell Junctions through trans-Heterophilic Interaction with CD155, a Vitronectin and Poliovirus Receptor That Localizes to αvβ3 Integrin-containing Membrane Microdomains*
TLDR
Findings demonstrate the possible trans-interaction between the bona fide cell-cell adherens type adhesion system (cadherin/nectin) and the cell-matrix adhesionSystem (integrin/CD155) by virtue of their nectin-3 and CD155 components, respectively.
Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression.
TLDR
It is demonstrated that transcriptional regulation of cyclin D1 by FAK signaling pathways contributes to the regulation of cell cycle progression in cell adhesion.
CD155/PVR plays a key role in cell motility during tumor cell invasion and migration
TLDR
A functional proteomic screen has identified CD155 (the poliovirus receptor) as a mediator of tumor cell invasion through its role in migration and suggests that CD155 may contribute to tumorigenesis.
Regulation of the Cell Cycle by Focal Adhesion Kinase
TLDR
Results have identified FAK and its associated signaling pathways as a mediator of the cell cycle regulation by integrins.
SHP-1- and Phosphotyrosine-Independent Inhibitory Signaling by a Killer Cell Ig-Like Receptor Cytoplasmic Domain in Human NK Cells1
TLDR
In human NK cell lines, a retroviral transduction method is used to show that the single ITIM of 2DL4 efficiently inhibits natural cytotoxicity responses and reveals new aspects of the KIR-inhibitory pathway in human NK cells, which are SHP-1 and phosphotyrosine independent.
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