The CD155/poliovirus receptor enhances the proliferation of ras‐mutated cells

  title={The CD155/poliovirus receptor enhances the proliferation of ras‐mutated cells},
  author={Tokuyuki Kono and Yasuo Imai and Shin-ichi Yasuda and Kyoko Ohmori and Hirokazu Fukui and Kazuhito Ichikawa and Shigeki Tomita and Johji Imura and Yoshikazu Kuroda and Yoshihiko Ueda and Takahiro Fujimori},
  journal={International Journal of Cancer},
Stimulation of the CD155/poliovirus receptor, which localizes in the cell–matrix and at cell–cell junctions, inhibits cell adhesion and enhances cell migration. Necl‐5, a mouse homolog of CD155, is implicated in the formation of adherence junctions. Recently, Necl‐5 has also been found to enhance cell proliferation via the stimulation of serum and platelet‐derived growth factor through the Ras‐Raf‐MEK‐ERK signaling pathway. In our present study, we find that CD155 significantly enhances the… 
Oncolytic virotherapy for human bone and soft tissue sarcomas using live attenuated poliovirus.
The results suggest that oncolytic therapy using a LAPV may represent a new option for the treatment of bone and soft tissue sarcoma and the effect of live attenuated poliovirus (LAPV) caused growth suppression of the tumors.
Tissue-dependent T Cell Apoptosis and Transcriptional Regulation of Memory CD8+T Cell Differentiation During Viral Infections: A Dissertation
Mechanisms regulating tissue-dependent differences in CD8T cell apoptosis were studied in an acute LCMV infection model and the presence of these antigenic markers correlated with increased memory potential and survival.
Expression Patterns of Poliovirus Receptor, Erythrocyte Protein Band 4.1-Like 3, Regulator of G-Protein Signaling 11, and Oxytocin Receptor in Mouse Ovarian Cells During Follicle Growth and Early Luteinization In Vitro and In Vivo1
Poliovirus receptor, erythrocyte protein band 4.1-like 3, regulator of G-protein signaling 11, and oxytocin receptor expression were quantified in in vitro- and in vivo-grown mouse follicles, and Rgs11 and Oxtr are both in vivo and in vitro upregulated in cumulus cells during antral follicle growth and might be considered positive markers for follicle development.
Dually regulating the proliferation and the immune microenvironment of melanoma via nanoparticle-delivered siRNA targeting onco-immunologic CD155.
This study proposed silencing the CD155 of melanoma cells and melanoma-infiltrating macrophages by a nanoparticle-delivered small interference RNA (siRNA) targeting CD155 (siCD155).
Differential expression of poliovirus receptor, regulator of G-protein signaling 11 and erythrocyte protein band 4.1-like 3 in human granulosa cells during follicular growth and maturation
  • E. BarzilayY. Yung A. Hourvitz
  • Biology
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2014
During human follicular maturation there are significant changes in expression of PVR, RGS11 and EPB41L3, possibly regulated by progesterone.
Molecular Pathways: Targeting CD96 and TIGIT for Cancer Immunotherapy
A review of the rationale behind targeting CD96 and TIGIT, and the potential approaches in translating these preclinical findings into novel clinical agents is discussed, to highlight these pathways as promising new targets for immune modulation.
Profiling killers; unravelling the pathways of human natural killer cell function.
Some of the basic features of NK cell biology are illustrated and the contribution made by post-genomic technology in defining the molecular mechanisms by which NK cells identify and kill susceptible targets is highlighted.
Targeting CD155 by rediocide-A overcomes tumour immuno-resistance to natural killer cells
Red-A overcomes immuno-resistance of NSCLCs to NK cells by down-regulating CD155 expression, which shows the possibility of developing checkpoint inhibitors targeting TIGIT/CD155 signalling to overcome immuno'sistance of cancer cells.


Ligand stimulation of CD155alpha inhibits cell adhesion and enhances cell migration in fibroblasts.
Enhancement of Serum- and Platelet-derived Growth Factor-induced Cell Proliferation by Necl-5/Tage4/Poliovirus Receptor/CD155 through the Ras-Raf-MEK-ERK Signaling*
Results indicate that Necl-5 plays roles not only in cell motility but also in cell proliferation, as well as being involved at least partly in the enhanced proliferation of transformed cells including NIH3T3 cells transformed by an oncogenic Ras or v-Src.
Nectin-like Molecule-5/Tage4 Enhances Cell Migration in an Integrin-dependent, Nectin-3-independent Manner*
Results indicate that Necl-5 regulates serum- and platelet-derived growth factor-induced cell migration in an integrin-dependent, nectin-3-independent manner, when cells do not contact other cells.
CD155/PVR enhances glioma cell dispersal by regulating adhesion signaling and focal adhesion dynamics.
It is shown that expression of CD155/PVR in rat glioma cells that normally lack this protein enhances their dispersal both in vitro and on primary brain tissue, and suggests a pathway through which gliomas and other cancer cells may acquire a dispersive phenotype.
p27Kip1 and Cyclin D1 Are Necessary for Focal Adhesion Kinase Regulation of Cell Cycle Progression in Glioblastoma Cells Propagated in Vitro and in Vivo in the Scid Mouse Brain*
The results indicate that FAK promotes proliferation of glioblastoma cells by enhancing exit from G1 through a mechanism that involves cyclin D1 and p27Kip1.
Recruitment of Nectin-3 to Cell-Cell Junctions through trans-Heterophilic Interaction with CD155, a Vitronectin and Poliovirus Receptor That Localizes to αvβ3 Integrin-containing Membrane Microdomains*
Findings demonstrate the possible trans-interaction between the bona fide cell-cell adherens type adhesion system (cadherin/nectin) and the cell-matrix adhesionSystem (integrin/CD155) by virtue of their nectin-3 and CD155 components, respectively.
Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression.
It is demonstrated that transcriptional regulation of cyclin D1 by FAK signaling pathways contributes to the regulation of cell cycle progression in cell adhesion.
CD155/PVR plays a key role in cell motility during tumor cell invasion and migration
A functional proteomic screen has identified CD155 (the poliovirus receptor) as a mediator of tumor cell invasion through its role in migration and suggests that CD155 may contribute to tumorigenesis.
Regulation of the Cell Cycle by Focal Adhesion Kinase
Results have identified FAK and its associated signaling pathways as a mediator of the cell cycle regulation by integrins.
SHP-1- and Phosphotyrosine-Independent Inhibitory Signaling by a Killer Cell Ig-Like Receptor Cytoplasmic Domain in Human NK Cells1
In human NK cell lines, a retroviral transduction method is used to show that the single ITIM of 2DL4 efficiently inhibits natural cytotoxicity responses and reveals new aspects of the KIR-inhibitory pathway in human NK cells, which are SHP-1 and phosphotyrosine independent.