The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors.

@article{Means1999TheCL,
  title={The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors.},
  author={Terry K. Means and Egil Lien and A Yoshimura and Siying Wang and Douglas T Golenbock and Matthew J. Fenton},
  journal={Journal of immunology},
  year={1999},
  volume={163 12},
  pages={6748-55}
}
Mammalian Toll-like receptor (TLR) proteins are new members of the IL-1 receptor family that participate in activation of cells by bacteria and bacterial products. Several recent reports indicate that TLR proteins mediate cellular activation by bacterial LPS via a signaling pathway that is largely shared by the type I IL-1 receptor. We previously showed that Chinese hamster ovary (CHO) fibroblasts engineered to express CD14 (CHO/CD14) were responsive to LPS, but not to a distinct CD14 ligand… CONTINUE READING
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