The CD14+ CD16+ blood monocytes: their role in infection and inflammation

@article{ZieglerHeitbrock2007TheCC,
  title={The CD14+ CD16+ blood monocytes: their role in infection and inflammation},
  author={Loems Ziegler‐Heitbrock},
  journal={Journal of Leukocyte Biology},
  year={2007},
  volume={81}
}
Blood monocyte subpopulations have been defined in man initially, and the two major types of monocytes are the CD14++ CD16− and the CD14+ CD16+ monocytes. These cells have been shown to exhibit distinct phenotype and function, and the CD14+ CD16+ were labeled proinflammatory based on higher expression of proinflammatory cytokines and higher potency in antigen presentation. The current review describes these properties, including the relationship to dendritic cells, and summarizes the host of… Expand
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The novel subset of CD14+/CD16+ blood monocytes is expanded in sepsis patients
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Three-color immunofluorescence shows that the CD14+/CD16+ monocytes in septicemia patients when compared with theCD14++ monocytes exhibit a higher level of class II antigen and a lower level of CD11b and CD33 antigens, consistent with a more mature nature of the CD 14+/ CD16+ cells. Expand
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