The CCR2+ Macrophage Subset Promotes Pathogenic Angiogenesis for Tumor Vascularization in Fibrotic Livers

@inproceedings{Bartneck2019TheCM,
  title={The CCR2+ Macrophage Subset Promotes Pathogenic Angiogenesis for Tumor Vascularization in Fibrotic Livers},
  author={Matthias Bartneck and Peter L. Schrammen and Diana Moeckel and Olivier Govaere and Anke Liepelt and Oliver Krenkel and Can Ergen and Misti Vanette McCain and Dirk Eulberg and Tom Luedde and Christian Trautwein and Fabian Kiessling and Helen Louise Reeves and Twan Lammers and Frank Tacke},
  booktitle={Cellular and molecular gastroenterology and hepatology},
  year={2019}
}
BACKGROUND & AIMS Hepatocellular carcinoma (HCC) typically arises in fibrotic or cirrhotic livers, which are characterized by pathogenic angiogenesis. Myeloid immune cells, specifically tumor-associated macrophages (TAMs), may represent potential novel therapeutic targets in HCC, complementing current ablative or immune therapies. However, the detailed functions of TAM subsets in hepatocarcinogenesis have remained obscure. METHODS TAM subsets were analyzed in-depth in human HCC samples and a… CONTINUE READING
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