The CCN family proteins in carcinogenesis.

  title={The CCN family proteins in carcinogenesis.},
  author={Animesh Dhar and Amitabha Ray},
  journal={Experimental oncology},
  volume={32 1},
The CCN (Cyr61 (cysteine-rich protein 61), CTGF (connective tissue growth factor), Nov (nephroblastoma overexpressed)) family consists of six members that belong to matricellular proteins of extracellular matrix (ECM). Like other matricellular proteins, CCN members do not primarily have a structural role; however, they modulate cell-ECM interactions. In general, CCN proteins are formed by four characteristic domain structures and thought to participate in various biological phenomena such as… CONTINUE READING


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