The CCL2-CCR2 system affects the progression and clearance of intracerebral hemorrhage.

  title={The CCL2-CCR2 system affects the progression and clearance of intracerebral hemorrhage.},
  author={Yao Yao and Stella E. Tsirka},
  volume={60 6},
Intracerebral hemorrhage (ICH) has been associated with inflammation and apoptosis. The CCL2-CCR2 chemotactic system is one of the major signaling pathways that induce inflammation and apoptosis. However, its role on ICH has not been investigated. We subjected wild-type, CCL2(-/-) , and CCR2(-/-) mice to collagenase-induced ICH, and assessed histological and behavioral outcomes. Lack of CCL2 or CCR2 decreased the hematoma volume early after collagenase-induced ICH but delayed its recovery. The… CONTINUE READING


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