The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes

@article{Tiala2006TheC,
  title={The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes},
  author={Inkeri Tiala and Sari Suomela and Jari Huuhtanen and Janica Wakkinen and Maarit H{\"o}ltt{\"a}-Vuori and Kati Kainu and Sirpa Ranta and Ursula Turpeinen and Esa H{\"a}m{\"a}l{\"a}inen and Hong Jiao and Seija-Liisa Karvonen and Elina Ikonen and Juha Kere and Ulpu Saarialho-Kere and Outi Elomaa},
  journal={Journal of Molecular Medicine},
  year={2006},
  volume={85},
  pages={589-601}
}
The HCR gene, officially called Coiled-Coil α-Helical Rod protein 1 (CCHCR1), located within the major psoriasis susceptibility locus PSORS1, is a plausible candidate gene for the risk effect. Recently, CCHCR1 was shown to promote steroidogenesis by interacting with the steroidogenic acute regulator protein (StAR). Here, we examined the role of CCHCR1 in psoriasis and cutaneous steroid metabolism. We found that CCHCR1 and StAR are expressed in basal keratinocytes in overlapping areas of the… CONTINUE READING

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