The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development.

@article{Samuelsson1991TheCB,
  title={The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development.},
  author={Lena Samuelsson and K. H. Patrik Str{\"o}mberg and K Vikman and G. Bjursell and Sven Enerb{\"a}ck},
  journal={The EMBO journal},
  year={1991},
  volume={10 12},
  pages={3787-93}
}
During the course of differentiation of preadipocytes into adipocytes, several differentiation-linked genes are activated synchronously with morphological changes. To follow this process we have used 3T3-F442A cells, known to undergo adipocyte conversion with high frequency. Accumulation of lipid droplets in the cytoplasm constitutes an easily visualized sign of the terminally differentiated phenotype. In this report we demonstrate that expression of the CCAAT/enhancer binding protein (C/EBP… CONTINUE READING

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