The CBP coactivator functions both upstream and downstream of Dpp/Screw signaling in the early Drosophila embryo.

@article{Lilja2003TheCC,
  title={The CBP coactivator functions both upstream and downstream of Dpp/Screw signaling in the early Drosophila embryo.},
  author={Tobias Lilja and Dai Qi and Marianne Stabell and Mattias Mannervik},
  journal={Developmental biology},
  year={2003},
  volume={262 2},
  pages={294-302}
}
The CBP histone acetyltransferase plays important roles in development and disease by acting as a transcriptional coregulator. A small reduction in the amount of Drosophila CBP (dCBP) leads to a specific loss of signaling by the TGF-beta molecules Dpp and Screw in the early embryo. We show that the expression of Screw itself, and that of two regulators of Dpp/Screw activity, Twisted-gastrulation and the Tolloid protease, is compromised in dCBP mutant embryos. This prevents Dpp/Screw from… CONTINUE READING

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