The CATH Hierarchy Revisited—Structural Divergence in Domain Superfamilies and the Continuity of Fold Space

@inproceedings{Cuff2009TheCH,
  title={The CATH Hierarchy Revisited—Structural Divergence in Domain Superfamilies and the Continuity of Fold Space},
  author={Alison Cuff and Oliver C. Redfern and Lesley H. Greene and Ian Sillitoe and Tony Lewis and Mark Dibley and Adam James Reid and Frances M. G. Pearl and Tim Dallman and Annabel E. Todd and Richard Garratt and Janet M. Thornton and Christine A. Orengo},
  booktitle={Structure},
  year={2009}
}
This paper explores the structural continuum in CATH and the extent to which superfamilies adopt distinct folds. Although most superfamilies are structurally conserved, in some of the most highly populated superfamilies (4% of all superfamilies) there is considerable structural divergence. While relatives share a similar fold in the evolutionary conserved core, diverse elaborations to this core can result in significant differences in the global structures. Applying similar protocols to examine… CONTINUE READING
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