The CARD15 2936insC mutation and TLR4 896 A>G polymorphism in African Americans and risk of preterm premature rupture of membranes (PPROM).

@article{Ferrand2002TheC2,
  title={The CARD15 2936insC mutation and TLR4 896 A>G polymorphism in African Americans and risk of preterm premature rupture of membranes (PPROM).},
  author={Pedro E Ferrand and Toshio Fujimoto and Vargheese M Chennathukuzhi and Samuel Parry and George A Macones and Mary D. Sammel and Helena Kuivaniemi and Roberto Romero and Jerome F Strauss},
  journal={Molecular human reproduction},
  year={2002},
  volume={8 11},
  pages={
          1031-4
        }
}
  • Pedro E Ferrand, Toshio Fujimoto, +6 authors Jerome F Strauss
  • Published in Molecular human reproduction 2002
  • Biology, Medicine
  • Infection is believed to be a leading cause of preterm premature rupture of membranes (PPROM). The bacterial cell wall component, lipopolysaccharide (LPS), is thought to initiate tissue responses leading to PPROM in the setting of Gram negative infection. LPS is recognized by the innate immune system, including the proteins encoded by the CARD15 and TLR4 genes. A recently described mutation (2936insC) in CARD15 and a polymorphism in TLR4 896 A>G impair responses to LPS. The objective of this… CONTINUE READING

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