The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila.

@article{Xu2005TheCC,
  title={The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila.},
  author={Dongbin Xu and Ying Li and Michael J Arcaro and Melinda Lackey and Andreas Bergmann},
  journal={Development},
  year={2005},
  volume={132 9},
  pages={2125-34}
}
The initiator caspase Dronc is the only Drosophila caspase that contains a caspase activation and recruitment domain (CARD). Although Dronc has been implicated as an important effector of apoptosis, the genetic function of dronc in normal development is unclear because dronc mutants have not been available. In an EMS mutagenesis screen, we isolated four point mutations in dronc that recessively suppress the eye ablation phenotype caused by eye-specific overexpression of hid. Homozygous mutant… CONTINUE READING
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