The CAG repeat polymorphism within the androgen receptor gene and maleness.

@article{Zitzmann2003TheCR,
  title={The CAG repeat polymorphism within the androgen receptor gene and maleness.},
  author={M. Zitzmann and Eberhard Nieschlag},
  journal={International journal of andrology},
  year={2003},
  volume={26 2},
  pages={76-83}
}
The androgen testosterone and its metabolite dihydrotestosterone exert their effects on gene expression and thus effect maleness via the androgen receptor (AR). A diverse range of clinical conditions starting with complete androgen insensitivity has been correlated with mutations in the AR. Subtle modulations of the transcriptional activity induced by the AR have also been observed and frequently assigned to a polyglutamine stretch of variable length within the N-terminal domain of the receptor… CONTINUE READING