The CA 125 Gene: An Extracellular Superstructure Dominated by Repeat Sequences

  title={The CA 125 Gene: An Extracellular Superstructure Dominated by Repeat Sequences},
  author={Timothy J O'brien and John B. Beard and Lowell J. Underwood and Richard A Dennis and Alessandro D. Santin and Lyndal York},
  journal={Tumor Biology},
  pages={348 - 366}
CA 125 has long presented problems to both clinicians and investigators because there was no definitive information on its structure and function. Here, we describe our work on cloning the CA 125 gene with the anticipation that such information will provide the basis for understanding its structure and its physiologic role in both normal and malignant tissues. The CA 125 protein core is composed of a short cytoplasmic tail, a transmembrane domain and an extraordinarily large glycosylated… 

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