The C677T methylenetetrahydrofolate reductase polymorphism influences the homocysteine-lowering effect of hormone replacement therapy.

@article{Brown1999TheCM,
  title={The C677T methylenetetrahydrofolate reductase polymorphism influences the homocysteine-lowering effect of hormone replacement therapy.},
  author={Charlotte A. Brown and Kimberly Q. McKinney and Karen Young and Harry James Norton},
  journal={Molecular genetics and metabolism},
  year={1999},
  volume={67 1},
  pages={43-8}
}
Elevated homocysteine is an independent risk factor for cardiovascular disease and has been associated with a common C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene. Estrogen use has been shown to reduce homocysteine concentrations, suggesting that this might contribute to the cardiovascular benefit of hormone replacement therapy. We examined 90 postmenopausal women to determine if MTHFR genotype affected the response of homocysteine to hormone replacement therapy… CONTINUE READING
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The effect of 677C>T and 1298A>C MTHFR polymorphisms on sulfasalazine treatment outcome in rheumatoid arthritis.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas • 2009

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