The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction.

  title={The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction.},
  author={Claire E Bamberg and Charles R Mackay and Hyun Bok Lee and David Zahra and Jenny Jackson and Yun Si Lim and Peter L Whitfeld and Stewart Craig and Erin M. Corsini and Bao Shi Lu and Craig Gerard and Norma P. Gerard},
  journal={The Journal of biological chemistry},
  volume={285 10},
The complement anaphylatoxin C5a is a proinflammatory component of host defense that functions through two identified receptors, C5a receptor (C5aR) and C5L2. C5aR is a classical G protein-coupled receptor, whereas C5L2 is structurally homologous but deficient in G protein coupling. In human neutrophils, we show C5L2 is predominantly intracellular, whereas C5aR is expressed on the plasma membrane. Confocal analysis shows internalized C5aR following ligand binding is co-localized with both C5L2… CONTINUE READING
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