The C5 protein encoded by Ageratum leaf curl Sichuan virus is a virulence factor and contributes to the virus infection

@article{Li2021TheCP,
  title={The C5 protein encoded by Ageratum leaf curl Sichuan virus is a virulence factor and contributes to the virus infection},
  author={Pengbai Li and Feng Su and Qiyuan Meng and Hua-shi Yu and Gentu Wu and Mingjun Li and Ling Qing},
  journal={Molecular Plant Pathology},
  year={2021},
  volume={22},
  pages={1149 - 1158}
}
Abstract Earlier reports have indicated that begomoviruses encode four proteins (AC1/C1, AC2/C2, AC3/C3, and AC4/C4 proteins) using complementary‐sense DNA as the template. In recent years, several reports have shown that some begomoviruses also encode an AC5/C5 protein from the complementary DNA strand, and these AC5/C5 proteins play different roles in virus infections. Here, we provide evidence showing that Ageratum leaf curl Sichuan virus (ALCScV), a monopartite begomovirus, also encodes a… 
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References

SHOWING 1-10 OF 38 REFERENCES
The AC5 protein encoded by Mungbean yellow mosaic India virus is a pathogenicity determinant that suppresses RNA silencing-based antiviral defenses.
TLDR
It is demonstrated that MYMIV AC5 is a pathogenicity determinant and a potent RNA silencing suppressor that employs novel mechanisms to suppress antiviral defenses, and suggested that the AC5 function may be conserved among many begomoviruses.
Analysis of Pathogenicity and Virulence Factors of Ageratum leaf curl Sichuan virus
Ageratum leaf curl Sichuan virus (ALCScV) is a novel monopartite begomovirus, which was identified from Ageratum conyzoides plants in Sichuan Province, China. In this study, we showed that ALCScV can
The AC4 Protein of a Cassava Geminivirus Is Required for Virus Infection.
TLDR
Results show involvement of EACMCV AC4 in virus infectivity; they also suggest a role for the combined action of mutation and selection, under prevailing environmental conditions, on begomovirus genetic variation and diversity.
The Malvastrum Yellow Vein Virus C4 Protein Promotes Disease Symptom Development and Enhances Virus Accumulation in Plants
TLDR
The results indicate that the MaYVV C4 protein is a determinant of disease symptom and viral DNA accumulation and this protein can also function as a suppressor of RNA silencing and alter cell division and expansion.
Cotton Leaf Curl Multan virus C4 protein suppresses both transcriptional and post-transcriptional gene silencing by interacting with SAM synthetase
TLDR
It is reported that Cotton Leaf Curl Multan virus (CLCuMuV) C4 protein interacts with S-adenosyl methionine synthetase (SAMS), a core enzyme in the methyl cycle, and inhibits SAMS enzymatic activity.
Geminivirus C3 Protein: Replication Enhancement and Protein Interactions
TLDR
Investigating the impact of mutations to amino acids that are conserved across the C3 protein family on replication enhancement and protein interactions in dicot-infecting geminivirus replication established the importance of C3-C3, C2-C1, and C4-PCNA interactions in geminIVirus replication.
Toward understanding the molecular mechanism of a geminivirus C4 protein
TLDR
A model of how C4 functions is proposed, which demonstrates that C4 interacts with 7 of the 10 members of the Arabidopsis thaliana SHAGGY-like protein kinase gene family and characterized the interactions of C4 and C4 mutants with AtSKs.
The role of AV2 ("precoat") and coat protein in viral replication and movement in tomato leaf curl geminivirus.
TLDR
The results demonstrated that multiple functions provided by AV2, BV1, BC1 are essential for viral movement, and that changes in A-component virion-sense mRNA structure or translation affect viral replication.
A recombinant begomovirus resulting from exchange of the C4 gene.
TLDR
The results indicate that TLCYnV evolved from TYLCCNV by recombination, acquiring a more virulent C4, allowing it to dispense with the requirement for a betasatellite.
Characterization of Curtovirus V2 Protein, a Functional Homolog of Begomovirus V2
TLDR
It is demonstrated that V2 from BCTV is able to induce systemic symptoms and necrosis associated with a hypersensitive response-like (HR-like) when expressed from Potato virus X vector in N. benthamiana, and that this pathogenicity activity does not dependent of its ability to supress PTGS.
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