The C5 convertase is not required for activation of the terminal complement pathway in murine experimental cerebral malaria.

@article{Ramos2012TheCC,
  title={The C5 convertase is not required for activation of the terminal complement pathway in murine experimental cerebral malaria.},
  author={Theresa N. Ramos and Meghan M. Darley and Sebastian Weckbach and Philip F. Stahel and Stephen Tomlinson and Scott Robert Barnum},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 29},
  pages={24734-8}
}
Cerebral malaria (CM) is the most severe manifestation of clinical malaria syndromes and has a high fatality rate especially in the developing world. Recent studies demonstrated that C5(-/-) mice are resistant to experimental CM (ECM) and that protection was due to the inability to form the membrane attack complex. Unexpectedly, we observed that C4(-/-) and factor B(-/-) mice were fully susceptible to disease, indicating that activation of the classical or alternative pathways is not required… CONTINUE READING