The C3H/HeJ inbred mouse is a model of vesico-ureteric reflux with a susceptibility locus on chromosome 12.

@article{Murawski2010TheCI,
  title={The C3H/HeJ inbred mouse is a model of vesico-ureteric reflux with a susceptibility locus on chromosome 12.},
  author={Inga J. Murawski and Rita W Maina and Danielle Malo and L. M. Guay-Woodford and Philippe Gros and Mary Fujiwara and Kenneth Morgan and Indra Rani Gupta},
  journal={Kidney international},
  year={2010},
  volume={78 3},
  pages={269-78}
}
Vesico-ureteric reflux is the most common congenital anomaly of the urinary tract, characterized by a defective uretero-vesical junction with retrograde urine flow from the bladder toward the kidneys. Because there is strong evidence for a genetic basis for some cases of vesico-ureteric reflux, we screened 11 inbred mouse strains for reflux and kidney size and identified one strain, C3H/HeJ, that has a 100 percent incidence of vesico-ureteric reflux with otherwise normal kidneys at birth. These… CONTINUE READING
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