The C282Y mutation in the haemochromatosis gene (HFE) and hepatitis C virus infection are independent cofactors for porphyria cutanea tarda in Australian patients.

@article{Stuart1998TheCM,
  title={The C282Y mutation in the haemochromatosis gene (HFE) and hepatitis C virus infection are independent cofactors for porphyria cutanea tarda in Australian patients.},
  author={Katherine A Stuart and Frances Busfield and Elizabeth C. Jazwinska and Paul Gibson and Lesley Butterworth and W. Graham E. Cooksley and Lawrie W. Powell and Darrell H. G. Crawford},
  journal={Journal of hepatology},
  year={1998},
  volume={28 3},
  pages={
          404-9
        }
}
BACKGROUND/AIM Whether mutations in the putative haemochromatosis gene (HFE) and hepatitis C virus act independently to precipitate porphyria cutanea tarda is unknown. The aim of the study was to investigate the relationship between mutations in HFE, hepatitis C and porphyria cutanea tarda. METHODS The frequencies of the C282Y and H63D mutations in HFE were determined in 27 patients with porphyria cutanea tarda and compared with the reported control frequencies. In addition, the presence of… CONTINUE READING

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