The C. elegans Tailless/TLX transcription factor nhr-67 controls neuronal identity and left/right asymmetric fate diversification.

@article{Sarin2009TheCE,
  title={The C. elegans Tailless/TLX transcription factor nhr-67 controls neuronal identity and left/right asymmetric fate diversification.},
  author={Sumeet Sarin and C{\'e}lia Ant{\'o}nio and Baris Tursun and Oliver Hobert},
  journal={Development},
  year={2009},
  volume={136 17},
  pages={2933-44}
}
An understanding of the molecular mechanisms of cell fate determination in the nervous system requires the elucidation of transcriptional regulatory programs that ultimately control neuron-type-specific gene expression profiles. We show here that the C. elegans Tailless/TLX-type, orphan nuclear receptor NHR-67 acts at several distinct steps to determine the identity and subsequent left/right (L/R) asymmetric subtype diversification of a class of gustatory neurons, the ASE neurons. nhr-67… CONTINUE READING